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Damage to cell membrane : It results due to continued influx of water, loss of membrane phospholipids and loss of protective amino acids (like glycine). Damage to cell membranes result in massive influx of calcium.
Calcium influx: Massive influx of Ca2+ results in the formation of large flocculent mitochondrial densities and activation of enzymes.
Nuclear changes: These are characterized by condensation of chromatin (pyknosis), fragmentation of the nucleus (karyorrhexis) and dissolution of the nucleus (karyolysis).
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Disease occurs due to alteration of the functions of tissues or cells at the microscopic level. The various causes of cell injury include: Hypoxia: It is the most common…
General Propertiest Machanism of action LAs block both the generation and the conduction of the nerve impulses The blockage results from biochemical changes caused by the drug on the…